Table 1. Pooled Distribution, Odds Ratios and 95% Confidence Intervals for the Association Between Chromosome 6p21 TagSNPs and NPC.
| SNP | Genotype | Case (%) | Control (%) | OR (95% CI)1 | OR (95% CI)2 |
| GABBR1 | |||||
| rs2076483 | |||||
| AA | 403 (68.8) | 273 (52.4) | 1 | 1 | |
| AG | 166 (28.3) | 213 (40.9) | 0.52 (0.40–0.68) | 0.72 (0.51–1.0) | |
| GG | 17 (2.9) | 35 (6.7) | 0.32 (0.18–0.59) | 0.71 (0.33–1.5) | |
| P- Trend | <0.0001 | 0.07 | |||
| rs29232 | |||||
| GG | 114 (19.4) | 171 (33.1) | 1 | 1 | |
| AG | 290 (49.5) | 259 (50.1) | 1.7 (1.3–2.3) | 1.3 (0.91–1.8) | |
| AA | 182 (31.1) | 87 (16.8) | 3.2 (2.2–4.5) | 1.9 (1.2–2.9) | |
| P- Trend | <0.0001 | 0.005 | |||
| HLA-F | |||||
| rs3129055 | |||||
| AA | 222 (37.8) | 246 (47.3) | 1 | 1 | |
| AG | 260 (44.2) | 231 (44.4) | 1.2 (0.96–1.6) | 0.90 (0.67–1.2) | |
| GG | 106 (18.0) | 43 (8.3) | 2.8 (1.9–4.2) | 1.4 (0.90–2.3) | |
| P- Trend | <0.0001 | 0.43 | |||
| HCG9 | |||||
| rs3869062 | |||||
| AA | 343 (60.0) | 223 (44.0) | 1 | 1 | |
| AG | 207 (36.2) | 232 (45.8) | 0.58 (0.45–0.74) | 0.67 (0.36–1.2) | |
| GG | 22 (3.9) | 52 (10.3) | 0.28 (0.17–0.47) | 1.0 (0.28–3.5) | |
| P- Trend | <0.0001 | 0.46 | |||
| rs16896923 | |||||
| AA | 413 (71.0) | 292 (56.8) | 1 | 1 | |
| AG | 163 (28.0) | 195 (37.9) | 0.59 (0.46–0.77) | 0.80 (0.55–1.2) | |
| GG | 6 (1.0) | 27 (5.3) | 0.16 (0.07–0.40) | 0.36 (0.13–1.0) | |
| P- Trend | <0.0001 | 0.07 | |||
1
adjusted for age, gender, study (study = CGU/CGMH or NTUH/MMH).
2
adjusted for age, gender, study, HLA-A.