Figure 6. Binding of m2a1 to sp62 and neutralization of HIV-1.

(A) Left: binding of m2a1 (▪) (EC₅₀ = 51 nM) and m01s (•) to sp62; binding of scrambled sp62 to m2a1 (□), m01s (○) was used as negative control. Right: binding of m66.6 to sp62 (▴) and scrambled sp62 (Δ). (B) Percentage inhibition of a panel of viruses pseudotyped with Envs of HIV-1 primary isolates by m2a1 at 5 µM (77 µg/ml) and m6 (positive control) at 0.5 µM (14 µg/ml), respectively. m01s at 5 µM (70 µg/ml) was used as negative control. Data are presented as mean ± SD.