Table 5. Performance Characteristics for Patients with CCC (n = 52).

	Cytology		Single gene expression			Combined gene expression profiles			Cytology/Gene expression#
	M = M	S&M = M	HOXB7	IGF2BP3	NEK2	1 positive	2 positive	3 positive
Sensitivity (%)	21.2	53.8	71.2	76.9	71.2	94.2	75.0	50.0	88.5
(95% CI)	(14.0–27.3)	(45.3–60.1)	(62.3–78.1)	(68.3–83.4)	(62.1–78.7)	(86.8–97.9)	(66.8–80.5)	(43.4–51.6)	(81.0–93.3)
Specificity (%)	85.1	85.1	78.7	80.9	72.3	46.8	87.2	97.9	87.2
(95% CI)	(77.2–91.9)	(75.6–92.0)	(68.9–86.4)	(71.4–88.0)	(62.3–80.7)	(38.6–50.9)	(78.2–93.3)	(90.6–99.6)	(78.9–92.6)
PPV (%)	61.1	80.0	78.7	81.6	74.0	66.2	86.7	96.3	88.5
(95% CI)	(40.5–78.7)	(87.3–89.2)	(68.9–86.4)	(72.5–88.5)	(64.6–81.8)	(61.0–68.8)	(77.2–93.1)	(83.6–99.3)	(81.0–93.3)
NPV (%)	49.4	62.5	71.2	76.0	69.4	88.0	75.9	63.9	87.2
(95% CI)	(44.8–53.3)	(55.5–67.5)	(62.3–78.1)	(67.1–82.7)	(59.8–77.4)	(72.6–95.7)	(68.0–81.2)	(59.1–65.0)	(78.9–92.6)
Accuracy (%)	51.5	68.7	74.7	78.8	71.7	71.7	80.8	72.7	87.9
(95% CI)	(44.0–57.9)	(59.7–75.2)	(65.4–82.1)	(69.8–85.6)	(62.2–79.6)	(63.9–75.6)	(72.2–86.6)	(65.8–74.4)	(80.0–92.9)

M = malignant; S&M = suspicious and malignant.

^#Cytology: M = S&M; Gene expression: 2 of 3 positive.