Table 5. Performance Characteristics for Patients with CCC (n = 52).
Cytology | Single gene expression | Combined gene expression profiles | Cytology/Gene expression# | ||||||
M = M | S&M = M | HOXB7 | IGF2BP3 | NEK2 | 1 positive | 2 positive | 3 positive | ||
Sensitivity (%) | 21.2 | 53.8 | 71.2 | 76.9 | 71.2 | 94.2 | 75.0 | 50.0 | 88.5 |
(95% CI) | (14.0–27.3) | (45.3–60.1) | (62.3–78.1) | (68.3–83.4) | (62.1–78.7) | (86.8–97.9) | (66.8–80.5) | (43.4–51.6) | (81.0–93.3) |
Specificity (%) | 85.1 | 85.1 | 78.7 | 80.9 | 72.3 | 46.8 | 87.2 | 97.9 | 87.2 |
(95% CI) | (77.2–91.9) | (75.6–92.0) | (68.9–86.4) | (71.4–88.0) | (62.3–80.7) | (38.6–50.9) | (78.2–93.3) | (90.6–99.6) | (78.9–92.6) |
PPV (%) | 61.1 | 80.0 | 78.7 | 81.6 | 74.0 | 66.2 | 86.7 | 96.3 | 88.5 |
(95% CI) | (40.5–78.7) | (87.3–89.2) | (68.9–86.4) | (72.5–88.5) | (64.6–81.8) | (61.0–68.8) | (77.2–93.1) | (83.6–99.3) | (81.0–93.3) |
NPV (%) | 49.4 | 62.5 | 71.2 | 76.0 | 69.4 | 88.0 | 75.9 | 63.9 | 87.2 |
(95% CI) | (44.8–53.3) | (55.5–67.5) | (62.3–78.1) | (67.1–82.7) | (59.8–77.4) | (72.6–95.7) | (68.0–81.2) | (59.1–65.0) | (78.9–92.6) |
Accuracy (%) | 51.5 | 68.7 | 74.7 | 78.8 | 71.7 | 71.7 | 80.8 | 72.7 | 87.9 |
(95% CI) | (44.0–57.9) | (59.7–75.2) | (65.4–82.1) | (69.8–85.6) | (62.2–79.6) | (63.9–75.6) | (72.2–86.6) | (65.8–74.4) | (80.0–92.9) |
M = malignant; S&M = suspicious and malignant.
Cytology: M = S&M; Gene expression: 2 of 3 positive.