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. 2012 Aug 7;7(8):e41952. doi: 10.1371/journal.pone.0041952

Figure 5. Impact of SR gene silencing on poly(I:C)-induced cytokine secretion by BEAS-2B cells.

Figure 5

BEAS-2B cells were treated with siRNA targeting CXCL16, LOX-1 and SR-B1 or the control siRNA (25 nM) and then activated with poly(I:C). (A) Inhibitory activity of RNA silencing on CXCL16, LOX-1, SR-B1 and SREC-1 mRNA expression was controlled by QRT-PCR. The reference corresponds to untreated cells (value  = 1). (B) RNA silencing of these SR inhibits the secretion of CXCL8, CXCL10, CCL5 and IL-29 induced by p(I:C). Data were expressed as the % of inhibition as compared with cells treated with the control siRNA (mean ± SEM) (n = 5). * p<0.05, n = 4.