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. 2012 Aug 7;7(8):e42207. doi: 10.1371/journal.pone.0042207

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© 2012 Huang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(♦) unlabeled RGD-hirudin inhibited platelet aggregation induced by ADP in a dose-dependent manner; (▪) ¹⁵N, ¹³C-labeled RGD-hirudin was same capable of inhibiting platelet aggregation induced by ADP; two samples 0.14 µmol/l could inhibit the platelet aggregation, and their inhibitory effect on the platelet aggregation were dose-response.