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ErbB4 pTyr site binding proteins. Four pYXN motifs of the ErbB4 cytosolic region were studied by pull-down MS and domain microarray. Identified binding proteins for each site are compared with Scansite predictions.
| ErbB4 site |
Sequence | Pull down | Microarray | Scansite |
|---|---|---|---|---|
| Y1162 | PMRDKPKQEpYLNPVEEN | Grb2 | Vav2; RASA1; Arg | PLCg; Grb2; Abl |
| Y1188 | DLQALDNPEpYHNASNGP | Grb2; Shc | Shc; Arg | Grb2; Shc |
| Y1202 | NGPPKAEDEpYVNEPLYL | Grb2 | Syk | Grb2; PLCg |
| Y1208 | EDEYVNEPLpYLNTFANT | Grb2 | - | - |
