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Nerve fiber count by capsaicin response. Participating subjects (n=97) received a 3 mm punch skin biopsy on the lower extremity six cm above the ankle. Intra-epidermal nerve fiber density (IENFD) was determined using the pan-axonal marker PGP 9.5 by a central laboratory (Therapath: www.therapath.com). Sites were selected for participation based on willingness to do skin biopsy and a prespecified intent to do the biopsy in about one half of the subjects.
