Table 2.
Clinical and demographic characteristics of pregnantmothers.
Group 1 (N=50) | Group 2 (N=32) | Group 3 (N=33) | P-value 1 vs. 2 | P-value 1 vs. 3 | |
---|---|---|---|---|---|
Clinical Diagnosis | 0.5 | 0.2 | |||
Asymptomatic | 15 (30%) | 7 (22%) | 5 (15%) | ||
UAS | 11 (22%) | 8 (25%) | 6 (18%) | ||
SS | 13 (26%) | 12 (38%) | 8 (24%) | ||
SLE/SS | 5 (10%) | 3 (9%) | 5 (15%) | ||
SLE | 4 (8%) | 2 (6%) | 7 (22%) | ||
Other/NA | 2 (4%) | 0 (0%) | 2 (6%) | ||
Race/ethnicity | 1.0 | 0.5 | |||
White | 41 (82%) | 25 (79%) | 11 (33%) | ||
Black | 2 (4%) | 2 (6%) | 0 (0%) | ||
Hispanic | 2 (4%) | 0 (0%) | 3 (9%) | ||
Asian | 4 (8%) | 3 (9%) | 1 (3%) | ||
Other/NA | 1 (2%) | 2 (6%) | 18 (55%) | ||
Antibody Status | |||||
Anti-Ro52 | 50 (100%) | 32 (100%) | 29 (88%) | 1.0 | 0.022 |
Anti-p200 | 44 (88%) | 31 (97%) | 22 (67%) | 0.2 | 0.026 |
Anti-Ro60 | 50 (100%) | 32 (100%) | 33 (100%) | 1.0 | 1.0 |
Anti-La | 26 (52%) | 19 (59%) | 17 (52%) | 0.6 | 1.0 |
Group 1: cardiac NL pregnancy, 3rd degree block (n=42), 2nd degree (n=1), 1st degree (n=3), cardiomyopathy (n=5), sinus bradycardia (n=2). Twins discordant for cardiac NL (n=4).
Group 2: unaffectedpregnancy, mother had aprevious child with cardiac NL. Healthy (n=29), cutaneous NL (n=4).
Group 3: unaffectedpregnancy, mother has only unaffected children, cutaneous NL (n=3), hepatic/hematological complications (n=1).
UAS= undifferentiated autoimmune syndrome, SS= Sjögren’s syndrome, SLE= systemic lupus erythematosus, NA= not available