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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Surgeon. 2012 Apr 23;10(6):350–356. doi: 10.1016/j.surge.2012.03.003

Figure 2.

Figure 2

Schematic overview illustrating the proposed integrated models of gut-origin sepsis. In this model system, gut injury or dysfunction can lead to bacterial translocation and systemic infection and/or the release of non-microbial gut-derived factors that potentiate the development of a septic state, ARDS and MODS. The bacterial translocation pathway leading to an increased incidence of systemic infections has been documented in several groups of surgical patients undergoing major procedures. The gut lymph pathway however appears to be the major mechanism of gut-origin sepsis in ICU patients.