Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The topotecan lactone clearance rate increases with age in a sigmoidal manner. Points represent individual clearance rates on day 1 of each cycle in which a pharmacokinetic study was performed. The curve and shaded region represent the median and 90% prediction interval determined by the nonlinear mixed-effects model.
