Table 2.
Grade 3 and 4 toxicities observed during RET5 window therapy
| Group | ||||
|---|---|---|---|---|
| G-CSF (n=17) |
No G-CSF (n=10) |
|||
| Grade 3 | Grade 4 | Grade 3 | Grade 4 | |
| n | n | n | n | |
| Hematologic toxicities | ||||
| Hemoglobin | 11 | 8 | ||
| Leukocytes (total WBC) | 3 | 1 | 3 | |
| Neutrophils/granulocytes (ANC/AGC) | 17 | 10 | ||
| Platelets | 8 | 3 | 1 | 4 |
| Non-hematologic toxicities | ||||
| Allergic reaction | 1 | |||
| Anorexia | 2 | 1 | ||
| Colitis, infectious (e.g., Clostridium difficile) | 1* | 1† | ||
| Dehydration | 2 | |||
| Diarrhea | 2 | 1 | 2 | |
| Febrile neutropenia | 2 | 3 | ||
| Fever without neutropenia | 1 | 1 | ||
| Glucose, serum-low (hypoglycemia) | 1 | |||
| Infection with Grade 3 or 4 neutropenia | 2‡ | |||
| Mucositis/stomatitis (clinical exam), Oral cavity | 2 | |||
| Pulmonary | 1 | |||
| Rash/desquamation | 2 | 1 | ||
| Vomiting | 1 | 1 | ||
Abbreviations: AGC, absolute granulocyte count; WBC, white blood cell count
*
This patient had clinical findings consistent with colitis and adenovirus was identified in the stool.
†
This patient had Clostridium difficile colitis and required intravenous antibiotics.
‡
One patient had balanitis and the other had respiratory syncytial virus infection.