Fig. 1.
Male Wistar rats were chronically treated for 21 consecutive days with duloxetine, DOV 216,303, or vehicle (H2O). Control animals received neither treatment nor handling. The hippocampus (a) and prefrontal cortex (b) were dissected 24 h after the last treatment, and total BDNF protein levels were measured. Both compounds reversed the reduction in hippocampal BDNF levels due to chronic oral administration. Prefrontal cortex BDNF levels increased after DOV 216,303 treatment only. Data are shown as mean values + SEM. *P < 0.05; **P < 0.01; ***P < 0.001