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Hippocampal HT22 cells were treated for 24 or 48 h with duloxetine or DOV 216,303. Intracellular BDNF levels were not altered by duloxetine or DOV 216,303 (a, b). Extracellular BDNF levels were significantly reduced after treatment with duloxetine or DOV 216,303, especially after 48-h treatment (c, d). Data are presented as mean values + SEM. *P < 0.05; **P < 0.01; ***P < 0.001
