Fig. 6.

Schematic overview of the obtained results. Activation of GR by agonist DEX activates the kinase CDK5, responsible for phosphorylation of its target proteins, including GR and MEF2. MEF2, now phosphorylated, is increasingly bound to the DNA where it is suggested to act as a transcriptional repressor. GR is also bound to the DNA under this condition. However, to what extent GR itself is responsible for c-JUN downregulation remains to be studied