Table 2.
Correlation between gene copy number gain (>1.3) and clinicopathological features
| Gene | Age (mean) young | Mitoses high (>8) | Mitoses (mean) high | Grade high (3) | LN meta negative | ER negative |
|---|---|---|---|---|---|---|
| ESR1 | ||||||
| EGFR | 0.038 | |||||
| FGFR1 | 0.019 | |||||
| ADAM9 | 0.043 | 0.017 | 0.004 | |||
| IKBKB | 0.033 | |||||
| PRDM14 | 0.049 | 0.003 | ||||
| MTDH | 0.019 | 0.005 | 0.003 | |||
| MYC | 0.023 | |||||
| CCND1 | 0.010 | |||||
| EMSY | 0.016 | |||||
| CDH1 | ||||||
| TRAF4 | ||||||
| CPD | 0.010 | |||||
| MED1 | 0.001 | <0.001 | <0.001 | |||
| HER2 | 0.025 | 0.003 | 0.014 | |||
| CDC6 | 0.027 | |||||
| TOP2A | 0.045 | 0.025 | 0.013 | |||
| MAPT | ||||||
| BIRC5 | 0.018 | 0.024 | <0.001 | |||
| CCNE1 | ||||||
| AURKA |
Tumor size and PR were not correlated with any of the studied genes (not shown). p values were calculated with Pearson Chi-square or Fisher’s exact test when appropriate (number of events <5) for categorical variables and ANOVA for continuous variables. Significant p values after correction for multiple comparison (Holm–Bonferroni method) are depicted in bold. See Supplementary Table 2 for full data
LN meta lymph node metastases