Fig. 1.

Distant metastasis-free survival likelihood ratio statistics of subtypes defined by the PAM50 or the SCMGENE predictors, after accounting for clinical–pathological variables (age at diagnosis, nodal status, treatment and tumor size). Models were first conditioned on one predictor and the clinical–pathological variables, and then the significance of the other was tested. (A – B) Entire combined dataset (n = 2,008), (C–D) subset of patients that did not receive adjuvant systemic therapy (n = 994), (E–F) subset of patients with HR+ tumors that received adjuvant tamoxifen-only (n = 491). Similar results are obtained if a term for dataset is included in the model