Table 4.
Study characteristics
| Reference | Species | n | Dose (mg/kg) | Timing of cyclosporin administration | Reperfusion time | Route | Assessment of infarct size | Infarct size |
|---|---|---|---|---|---|---|---|---|
| Karlsson et al. (2010) | Pigs | 27 | 10 | 3 min R | 120 min | IV | Pathology | %AAR |
| Lie et al. (2010) | Pigs | 38 | 10 | 5 min R | 180 min | IV | Pathology | %AAR |
| Troponin | ||||||||
| Boengler and Hilfiker-Kleiner (2010) | Mouse | 17 | 10 | 5 min R | 120 min | IV | Pathology | %AAR |
| Skychally et al. (2010) | Pigs | 8 | 5 | 5 min R | 120 min | IV | Pathology | %AAR |
| Matsubara et al. (2010) | Rabbits | 17 | 25 | 1 h I | 180 min | IV | Pathology | |
| 0 min R | ||||||||
| Dow et al. (2009) | Rats | 22 | 5 | 3 min R | 120 min | IV | Pathology | %AAR |
| 10 | ||||||||
| Pagel and Krolikowski (2009) | Rabbit | 12 | 5 | 5 min R | 180 min | IV | Pathology | %AAR |
| Gomez et al. (2008) | Mouse | 33 | 10 | 5 min R | 24 h | IV | Pathology | %AAR |
| Planimetry | ||||||||
| Fang et al. (2008) | Rats | 24 | 10 | 5 min R | 120 min | IV | Pathology | %AAR |
| Planimetry | ||||||||
| Leshnower et al. (2008) | Rabbit | 27 | 25 | 0 I | 3 h | IV | Pathology | %AAR |
| Planimetry | ||||||||
| Huhn et al. (2008) | Rats | 9 | 5 | 5 min R | 120 min | IV | Pathology | %AAR |
| Planimetry | ||||||||
| Lim et al. (2007) | Mouse | 7 | 10 | 0 min R | 120 min | IV | Pathology | %AAR |
| Planimetry | ||||||||
| Xie and Yu (2007) | Rats | 12 | 10 | 10 min I | 180 min | IV | Pathology | %LVA |
| EM | ||||||||
| Ikeda et al. (2006) | Rats | 13 | 5 | 15 I | 2 h | IV | Pathology | %AAR |
| Wang et al. (2006) | Rabbit | 16 | 10 | 5 min R | 180 min | IV | Pathology | %AAR |
| Argaud et al. (2005a) | Rabbit | 30 | 10 | 10 min I | 4 h | IV | Pathology | %LVW |
| 1 min R | Planimetry | |||||||
| Krolikowski et al. (2005) | Rabbit | 22 | 5 | 5 min R | 3 h | IV | Pathology | %AAR |
| 10 | ||||||||
| Argaud et al. (2004) | Rabbit | 47 | 10 | 15 min I | 4 h | IV | Pathology | %LVW |
| Planimetry | ||||||||
| Niemann et al. (2002) | Rat | 24 | 5 | 3 days I | 24 h | PO | Pathology | %AAR |
| Planimetry | ||||||||
| Squadrito et al. (1999) | Rats | 12 | 0.25 | 5 min A | 48 h | IV | Pathology | %AAR |
| 0.5 | ||||||||
| 1 | %LVA |
Cyclosporin was given either before ischemia (I), during ischemia and before reperfusion (R) or after ischaemia (A).
AAR = myocardial area at risk; EM = electron microscopy; IV = intravenous; LVA = total left ventricular area; LVW = left ventricular weight; PO = per oral.