Figure 1.

Location of the 271 residue on the glycine receptor α1 subunit. (A) In structural models of the pentameric glycine receptor (top view, left panel) and single α1 subunit (side-view, right panel) (Chung et al., 2010), the 271 residue (red) is physically located between the agonist binding site and the channel gate. The 12-amino-acid segment incorporating the 271 residue is highlighted in blue in the model of single α1 subunit. (B) Sequences of the M2 and M2–M3 domains of the glycine receptor α1, β and α1_Ch subunits are shown. The 271 residues are underlined.