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Effects of various substitutions of the 271 residue on the taurine sensitivity of the α1 and α1Ch glycine receptors. Example traces of currents induced by increasing taurine concentrations in the indicated constructs of the α1 and α1Ch glycine receptors are shown in (A) and (C), respectively. Averaged normalized taurine dose–response curves for various substitutions of the 271 residue of the α1 and α1Ch glycine receptors are shown in (B) and (D), respectively (n= 3 or 4).
