Table 2.
Drug levels in mouse tissues following oral administration of PS at 150 and 450 mg·kg−1
| Intact PS | PS sulphone | Sulindac | SSide | SSone | Sulindac glucuronide | SSone glucuronide | SSide glucuronide | |
|---|---|---|---|---|---|---|---|---|
| pmol·mg−1 protein (mean ± SEM) | ||||||||
| Dose = 150 mg·kg−1 | ||||||||
| Liver | 39 ± 17 | 18 ± 8 | 204 ± 49 | 19 ± 2 | 79 ± 42 | 15 ± 4 | 13 ± 3 | 25 ± 12 |
| Heart | 5 ± 1 | 1 ± 1 | 152 ± 34 | 12 ± 3 | 39 ± 7 | 2 ± 0 | 3 ± 0 | 1 ± 0 |
| Kidney | 4 ± 1 | 3 ± 1 | 499 ± 105 | 25 ± 7 | 94 ± 18 | 2 ± 1 | 3 ± 1 | 2 ± 0 |
| *Plasma | ND | ND | 64 ± 10 | 5 ± 1 | 14 ± 2 | 1 ± 0 | 1 ± 0 | 1 ± 0 |
| Dose = 450 mg·kg−1 | ||||||||
| Liver | 52 ± 8 | 17 ± 6 | 372 ± 40 | 21 ± 6 | 84 ± 40 | 66 ± 11 | 14 ± 2 | 17 ± 4 |
| Heart | 31 ± 6 | 8 ± 1 | 538 ± 63 | 19 ± 4 | 99 ± 27 | 22 ± 6 | 15 ± 4 | 4 ± 2 |
| Kidney | 14 ± 3 | 6 ± 1 | 888 ± 107 | 25 ± 8 | 136 ± 66 | 52 ± 15 | 10 ± 2 | 7 ± 2 |
| *Plasma | 5 ± 1 | 1 ± 0 | 157 ± 2 | 6 ± 2 | 26 ± 8 | 8 ± 2 | 4 ± 1 | 1 ± 0 |
*
Plasma levels were expressed as µM.
ND, not detectable.