Table 3.

Gastroduodenal drug levels in mice treated with PS or sulindac

	PS		Sulindac
	AUC0–24h in stomach-duodenum
	pmol·mg−1 protein*h	% of total	pmol·mg−1 protein*h	% of total
PS	16 698	71	0	0
PS sulphone	94	0	0	0
Sulindac	5 551	23	16 465	66
SSide	774	3	7 298	29
SSone	567	2	1 037	4
Total	23 684	100	24 800	100

PS 150 mg·kg⁻¹ or sulindac 100 mg·kg⁻¹ (equimolar) in corn oil were given orally once.

Samples were obtained at 0, 1, 2, 4, 8, 12 and 24 h post-dosing.

Values are the average of two mice; results from each pair were within 15%.