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. 2012 Apr;165(7):2191–2202. doi: 10.1111/j.1476-5381.2011.01706.x

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© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society

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Representative tracings for dose–response curves for tryptamine (A) and 5-HT (B and C) in rat isolated perfused mesenteric arteries. (A) Biphasic profile for tryptamine (0.01–1000 nmoles) in the presence of ritanserin (100 pM). (B) Biphasic response profile for 5-HT (0.01–1000 nmoles) in the presence of ritanserin (100 pM) alone and (C) in the presence of ritanserin (100 pM) and SB269970 (10 nM). The tissues were submaximally pre-constricted with 10 µM phenylephrine and continuously perfused for the duration of the experiment. Doses are the bolus dose in nmoles.