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. 2012 Apr;165(7):2191–2202. doi: 10.1111/j.1476-5381.2011.01706.x

Figure 8.

Figure 8

Effects of L-NAME (1 mM) on mean dose–response curves for the falls in perfusion pressure of rat isolated perfused mesenteric vascular beds in response to (A) tyramine, (B) β-PEA and (C). tryptamine. Tryptamine was examined in the continuous presence of ritanserin (100 pM). The perfusion pressure was raised by pre-constriction with phenylephrine (10 µM), which was continuously perfused for the duration of the experiment. Falls in perfusion pressure are shown as negative values, expressed as a percentage of the increase in perfusion pressure to phenylephrine. In control experiments, first (curve 1) and second (curve 2) dose–response curves for tyramine (A, n= 4), β-PEA (B, n= 6) and tryptamine (C, n= 4) were repeated to establish reproducibility. In separate experiments, dose–response curves for tyramine (A, n= 4), β-PEA (B, n= 5) and tryptamine in the presence of ritanserin (100 pM) (C, n= 4) were obtained in the absence and presence of L-NAME (1 mM). **P < 0.01 ***P < 0.001, significant effect of L-NAME; ANOVA followed byBonferroni post-test.