Table 1.
Potency orders of trace amines for the vasodilator responses of rat mesenteric vascular beds compared with published values for cAMP accumulation in rat TAAR-1 transfected cells, constriction of rat aorta and negative inotropy of rat isolated hearts
| −LogEC50 values (M) | ||||
|---|---|---|---|---|
| Vasodilatation in mesenteric bed | Tyramine | ß-PEA | Tryptaminea | Octopamine |
| 4.2 ± 1.5 | 3.63 ± 0.78 | 2.86 ± 0.09 | 2.59 ± 0.68 | |
| n= 4 | n= 8 | n= 7 | n= 4 | |
| Vasoconstriction in rat aorta Fehler et al. (2010) | Tryptaminea | ß-PEA | Octopamine | Tyramine (partial agonist) |
| 5.51 ± 0.12 | 4.46 ± 0.15 | 4.36 ± 0.17 | 3.71 ± 0.29 | |
| Negative inotropic responses in rat-isolated heartscFrascarelli et al. (2008) | Octopamine | ß-PEA | Tryptamine | Tyramine |
| 3.97 | 3.80 | 3.62 | 3.0 | |
| cAMP accumulation in rat TAAR-1 transfected cells Bunzow et al. (2001) | Tyramine | ß-PEA | Tryptamine | Octopamine |
| 7.16 | 6.62 | 6.51 | 5.89 | |
a
In the presence of ritanserin or ketanserin to block 5-HT2A receptors.