Table 1.

Biodistribution of ¹²⁵I-rhTRAIL in mice bearing human SKBR3 (A) or SW948 (B) xenografts (n= 4). Data are expressed as the %ID·g⁻¹ tissue ± SEM

(A)
	t = 15 min		t = 30 min		t = 60 min		t = 240 min
	125I-rhTRAIL	(±SEM)	125I-rhTRAIL	(±SEM)	125I-rhTRAIL	(±SEM)	125I-rhTRAIL	(±SEM)
Heart	2.4	0.2	0.8	0.1	1.1	0.2	0.2	0.0
Blood	6.3	0.3	2.1	0.4	2.9	0.2	0.4	0.1
Lung	3.8	0.2	1.7	0.3	2.3	0.2	0.4	0.1
Liver	4.9	0.3	1.5	0.3	1.4	0.1	0.2	0.0
Kidney	43.3	2.5	6.5	1.4	6.2	0.6	0.5	0.1
Bladder	3.7	1.3	7.5	5.0	10.2	4.0	1.1	0.3
Stomach	2.8	0.5	4.1	1.3	6.5	0.9	1.6	0.5
Pancreas	2.0	0.3	1.1	0.3	1.7	0.4	0.2	0.0
Spleen	3.1	0.1	1.6	0.3	2.0	0.3	0.3	0.1
Small intestine	2.7	0.3	1.9	0.6	3.2	1.3	0.3	0.1
Colon	2.4	0.6	1.0	0.1	2.1	0.6	0.3	0.2
Muscle	0.5	0.0	0.4	0.1	0.7	0.1	0.1	0.0
Bone	1.3	0.1	0.9	0.2	1.2	0.3	0.3	0.1
Brain	0.3	0.0	0.1	0.0	0.2	0.0	0.0	0.0
Tumour	1.5	0.2	2.1	0.4	2.8	0.4	0.4	0.1

(B)
	t = 15 min		t = 30 min		t = 60 min		t = 240 min
	125I-rhTRAIL	(±SEM)	125I-rhTRAIL	(±SEM)	125I-rhTRAIL	(±SEM)	125I-rhTRAIL	(±SEM)
Heart	2.5	0.2	2.3	0.1	1.7	0.1	0.3	0.1
Blood	6.6	0.7	4.6	0.6	3.6	0.1	0.8	0.2
Lung	4.2	0.5	3.7	0.3	3.1	0.2	0.7	0.1
Liver	6.7	0.6	5.7	0.2	1.8	0.2	0.4	0.1
Kidney	41.0	4.8	19.5	3.2	8.8	2.5	0.8	0.2
Bladder	4.7	1.5	8.3	1.0	4.1	0.9	2.3	0.6
Stomach	3.7	1.1	6.6	0.7	11.3	1.4	2.5	1.0
Pancreas	1.8	0.4	2.1	0.1	1.5	0.1	0.3	0.1
Spleen	4.0	0.6	4.2	0.5	2.5	0.3	0.6	0.1
Small intestine	3.9	0.4	3.9	0.6	2.4	0.3	0.8	0.1
Colon	1.6	0.2	1.9	0.2	1.5	0.1	0.4	0.1
Muscle	0.7	0.1	0.9	0.1	0.8	0.1	0.2	0.0
Bone	1.9	0.3	2.1	0.3	1.6	0.1	0.4	0.1
Brain	0.3	0.0	0.2	0.0	0.1	0.0	0.0	0.0
Tumour	2.0	0.5	2.9	0.3	3.6	0.4	1.0	0.1