Figure 4.

Allosteric positive modulators exhibit appropriate selectivity at concatemeric α4/δ-containing receptors. (A and B) Representative responses of oocytes expressing the indicated subunits to the indicated GABA concentrations and co-applied 1 µM lorazepam (Lzp). (C and D) Representative oocyte responses to the indicated GABA concentration and to co-applied DS2 (1 µM). (E and F) Oocytes lacking an auxiliary subunit failed to respond to either lorazepam or to DS2. (G) Lack of effect of ethanol (30 mM) and Ro15-4513 (0.3 µM) on GABA (0.5 µM)-activated concatemer currents.