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. 2012 Apr;165(7):2292–2303. doi: 10.1111/j.1476-5381.2011.01694.x

Figure 7.

Figure 7

Effect of bilateral orexin A (OX-A) injection in RVLM on the cardiovascular and respiratory response to hypoxia and hypercapnia. (A) Effect on the peripheral chemoreceptor reflex activated by brief hypoxia with 100% N2 for 12–14 s – experimental recording of hypoxic episodes at control period and after PBS or orexin A injection. (B) Grouped data of peak effects on cardiovascular (MAP, HR and sSNA) (top bar chart) and respiratory function (PNamp and PNf) (bottom bar chart) after injection of PBS and orexin A (50 pmol, n= 4) in response to brief hypoxia. (C) Effect on central chemoreceptor reflex activated by hypercapnia with 5% CO2 in O2 for 3 min – experimental recording of hypercapnic episodes at control period and after PBS or orexin A injection. (D) Comparison of peak effects on cardiovascular (MAP, HR and sSNA) and respiratory function (PNamp) after injection of PBS and orexin A (50 pmol, n= 5) in response to hypercapnia. Values are expressed as mean ± SE. Numbers of animals are shown in parentheses. ***P < 0.001, **P < 0.01, *P < 0.05, significantly different from control. bpm, beats per minute for HR or bursts per minute for PNf.