Figure 6.

Effect of Org 274179-0 on the potency and efficacy of TSH at stimulating TSH receptor activation. (A) CHO.hTSH receptor cells were incubated with the indicated concentrations of bTSH in the absence and presence of Org 274179-0 for 4 h followed by lysis of the cells and measurement of luciferase activity. Data are the duplicates of a single experiment, representative of three experiments. (B) Summary of the potencies of bTSH in the absence or presence of the indicated fixed concentrations of Org 274179-0. Data are the mean EC₅₀ or the mean pEC₅₀± SEM of three experiments.