Figure 8.

Chronic Sirolimus administration exacerbates glucose intolerance of rats fed a high-fat (HF) diet. Wistar rats were fed a HF diet for 6 weeks. During the last 3 weeks of the experiment, the animals fed the HF diet were divided into two groups, either treated with 2 mg·kg⁻¹·day⁻¹ Sirolimus (HF + SIR) or vehicle (HF). An additional control group of rats (CTL) was fed a standard diet for 6 weeks. (A) Glycaemia and (B) insulinaemia during glucose tolerance tests (1.5 g glucose·kg⁻¹) after 10 days of treatment. Values are mean ± SEM of six to seven rats per group. *P < 0.05 compared with standard diet fed controls. ^#P < 0.05 compared with HF-fed controls.