. 2012 Apr;165(7):2325–2340. doi: 10.1111/j.1476-5381.2011.01716.x

Table 3.

Insulin and glucose levels in rats fed a high fat diet

	Vehicle	Vehicle	Sirolimus
	Standard diet	HF diet	HF diet
Fasting insulinaemia (ng·mL⁻¹)	1.8 ± 0.2	2.3 ± 0.3	9.0 ± 0.8^a,b
Fasting glycaemia (mM)	5.2 ± 0.1	5.8 ± 0.2^a	5.8 ± 0.2^a
HOMA-IR	11.7 ± 1.3	17.4 ± 2.5	67.0 ± 6.9^a,b

Insulinaemia and glycaemia were measured after a 4 h period of fast. HOMA-IR was calculated as follows: (fasting plasma insulin in mU·L⁻¹) × (fasting plasma glucose in mM)/22.5. Values are mean ± SEM of six to seven animals per group.

^a,b

P < 0.05 using anova followed by the post hoc Bonferroni test, with significance compared with a: vehicle-treated standard-diet-fed group and b: vehicle-treated HF-fed group.