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. 2012 May 15;23(8):903–914. doi: 10.1089/hum.2012.015

FIG. 3.

FIG. 3.

(A and B) Cartography of ARSA expression in the brain of 10-month-old MLD mice, 2 months after a single injection of AAVrh.10cuARSA (A) or AAV5-PGK-ARSA (B) vector into the right striatum. (C and D) Representative immunostaining of human ARSA enzyme in a sagittal brain section of AAVrh.10-treated (C) and AAV5-treated mice (D). (E–J) After a single injection of AAVrh.10cuARSA vector into the right striatum, ARSA-positive cells were observed in several brain regions including the striatum (E), cortex (F), hippocampus (G), thalamus (H), ventral tegmental area (I), and interposed nucleus (J). cc, corpus callosum; ctx, cortex; hpf, hippocampus formation; hy, hypothalamus; ip, interposed nucleus; mgp, medial globus pallidus; pcg, pontine central nucleus; pg, pontine nucleus; sc, superior colliculus; sn, substantia nigra; STR, striatum; th, thalamus; vta, ventral tegmental area. Scale bars: 50 μm.