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Lipid analysis of NHP brain samples. Thalamic homogenates from PBS-treated controls and AAV2-hASM-treated NHPs were submitted for sphingolipidomic analysis, as described in Materials and Methods. Data are expressed as picomoles per milligram of total protein for each lipid or group of lipids analyzed (n=2 per group). (A) Total sphingomyelin; (B) total ceramide; (C) sphingosine; (D) sphingosine 1-phosphate.
