Table 1.
Protein function | VACV-COP | CPXV-GRI | MPXV-ZAI | VARV-IND | ||||
---|---|---|---|---|---|---|---|---|
ORF | Size, aa | ORF | Size, aa | ORF | Size, aa | ORF | Size, aa | |
Inhibition of NF-κB and IRF3 activation by interacting with MyD88, TIRAP and TRIF, and TRAM | A46R | 214 | A49R | 240 | A47R | 240 | A52R | 240 |
Inhibition of NF-κB activation by interacting with IRAK2 and TRAF6 | A52R | 190 | A55R | 190 | — | — | J6R | 71 |
Inhibition of NF-κB activation by interacting with IKK complex | B15R | 149 | B13R | 149 | B13R | 149 | B14R | 149 |
Inhibition of NF-κB and IRF3 activation by interacting with IKK complex and TBK1, apoptosis inhibitor | N1L | 117 | Q1L | 117 | P1L | 117 | P1L | 117 |
Inhibition of NF-κB and IRF3 activation by interacting with IRAK2, TRAF6, and DDX3 | K7R | 149 | M6R | 149 | C6R | 149 | C4R | 149 |
Inhibition of IRF3 and IRF7 activation by interacting with TANK, NAP1, and SINTBAD | C6L | 151 | C14L | 156 | D11L | 153 | D9L | 156 |
Unknown | C1L | 224 | C19L | 231 | D19L | 214 | D14L | 214 |
Unknown | C16L | 181 | D5L | 153 | — | — | D1L | 153 |
Unknown | N2L | 175 | Q2L | 175 | P2L | 177 | P2L | 177 |
VARV-IND: VARV strain India,1967, MPXV-ZAI: MPXV strain Zaire-I-96, CPXV-GRI: CPXV strain GRI-90, VAC-COP: VACV strain Copenhagen. ORF: open reading frame; aa: protein size in number of amino acid residues.