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Determination of water-soluble chitosan micro- and nanoparticles median lethal dose in rats
| Samples | Dose group (mg/kg) | Number | Mortality | Mortality rate |
|---|---|---|---|---|
| WSC | 1000 | 5 | 0 | 30% |
| 2150 | 5 | 0 | ||
| 4640 | 5 | 2 | ||
| 10,000 | 5 | 4 | ||
| WSC-MP | 1000 | 5 | 2 | 55% |
| 2150 | 5 | 2 | ||
| 4640 | 5 | 2 | ||
| 10,000 | 5 | 5 | ||
| WSC-NP | 1000 | 5 | 2 | 65% |
| 2150 | 5 | 1 | ||
| 4640 | 5 | 5 | ||
| 10,000 | 5 | 5 |
Abbreviations: WSC, water-soluble chitosan; WSC-MP, water-soluble chitosan microparticles; WSC-NP, water-soluble chitosan nanoparticles.
