Table 2.
The main pharmacokinetic parameters of compartment model estimation
| Parameter | Bufalin | BNPs |
|---|---|---|
| AUC(0-t) (mg/L*h) | 0.26 ± 0.02 | 0.11 ± 0.01 |
| AUC(0-∞) (mg/L*h) | 0.57 ± 0.02 | 0.43 ± 0.06 |
| MRT(0-t) (h) | 1.31 ± 0.11 | 2.32 ± 0.28 |
| MRT(0-∞) (h) | 3.45 ± 0.37 | 7.63 ± 0.85 |
| t1/2z (h) | 3.35 ± 0.31 | 7.17 ± 2.05 |
| Tmax (h) | 0.083 ± 0.011 | 0.083 ± 0.009 |
| Vz (L/kg) | 63.37 ± 1.56 | 187.83 ± 2.48 |
| Cmax (mg/L) | 0.61 ± 0.040 | 0.34 ± 0.011 |
Note: Values are mean ± standard deviation (n = 3).
Abbreviations: AUC, area under the curve; MRT, mean residence time; t1/2z, elimination half-life; Tmax, time of maximum concentration; Vz, apparent volume of distribution; Cmax, maximal concentration; BNPs, bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles.