Table IV.
Comparison of serum concentrations of sFlt1, PlGF and sEng among hypertensive women who delivered preterm infants with or without respiratory distress syndrome, in specimens collected at 10–20 or 21–32 weeks.
| RDS | No RDS | p value | |
|---|---|---|---|
| Collected at 10–20 weeks | |||
| Number of women | 18 | 55 | |
| GA at collection (weeks) | 15.9 ± 0.6* | 16.1 ± 0.4 | NS± |
| GA at delivery (weeks) | 31.2 ± 0.8 | 35.4 ± 0.2 | <0.001± |
| Cesarean section | 12 (66.7%) | 11 (20%) | <0.001±/NS† |
| Birth weight (g) | 1410 ± 155 | 2207 ± 64 | <0.001±/NS† |
| SGA | 8 (44.4%) | 17 (30.9%) | NS±/NS† |
| sFlt1 (pg/mL) | 4841 ± 1081 | 3216 ± 214 | 0.03±/NS† |
| PlGF (pg/mL) | 108 ± 33 | 115 ± 14 | NS±/NS† |
| sEng (ng/mL) | 8.31 ± 1.9 | 6.61 ± 0.4 | NS±/NS† |
| Collected at 21–32 weeks | |||
| Number of women | 17 | 53 | |
| GA at collection (weeks) | 27.9 ± 0.5 | 27.6 ± 0.2 | NS |
| GA at delivery (weeks) | 31.6 ± 0.8 | 35.2 ± 0.2 | <0.001± |
| Cesarean section | 11 (64.7%) | 11 (20.8%) | <0.001±/NS† |
| Birth weight (g) | 1420 ± 156 | 2201 ± 75 | <0.001±/NS† |
| SGA | 9 (52.9%) | 15 (28.3%) | NS±/0.045† |
| sFlt1 (pg/mL) | 21516 ± 3734 | 6998 ± 674 | <0.001±/0.01† |
| PlGF (pg/mL) | 215 ± 136 | 344 ± 56 | 0.002±/NS† |
| sEng (ng/mL) | 30.63 ± 5.7 | 16.07 ± 2.6 | 0.003±/NS† |
*
Data are presented as mean ± SD or N (%). Hypertensive = preeclampsia or gestational hypertension; RDS, respiratory distress syndrome; GA, gestational age; SGA, small for gestational age; sFlt1, soluble fms-like tyrosine kinase 1; PlGF, placental growth factor; sEng, soluble endoglin.
±
Indicates significance without adjustment.
†
Indicates significance with adjustment for gestational age at delivery.