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Schematic illustrations showing (A) the synthesis of a novel redox-responsive hyperbranched poly(amido amine) (named PCD) and (B) the formation of small interfering RNA (siRNA) ternary complexes with three different mixing orders.
Note: The ternary complexes were prepared in an optimized siRNA/PCD/hyaluronic acid (HA) charge ratio of 1/20/16.
Abbreviations: CBA, N, N′-cystamine bisacrylamide; DMDPTA, N, N′-dimethyldipropylenetriamine.
