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. 2012 Jul 18;7:3823–3835. doi: 10.2147/IJN.S29328

Figure 8.

Figure 8

Efficacy of nanocomplexes in suppressing the Bcl-2 mRNA expression in skov-3 cells, as quantified by real-time PCR analysis (n = 3).

Notes: For the nanocomplex pairs shown under the X-axis, the blank and grey bars show data for nanocomplexes delivering siRNA alone and nanocomplexes codelivering siRNA and DOX, respectively. Incubation time: 96 hours; N/P = 30; Dose: 25 nM siRNA per well. *P < 0.05, compared with D-FPPP/Bcl-2; #P < 0.05, compared with B-FPPP/Bcl-2 group; &P < 0.05, compared with D-FPPP/SCR; §P < 0.05, compared with D-NPPP/SCR.

Abbreviations: DOX, doxorubicin; D-PPP, DOX loaded poly(ethylene glycol)– poly(ethylene imine)–poly(ɛ-caprolactone) micelle; B-PPP, blank poly(ethylene glycol)–poly(ethylene imine)–poly(ɛ-caprolactone) micelle; FPPP/Bcl-2, Bcl-2 siRNA loaded folate–poly(ethylene glycol)–poly(ethylene imine)–poly(ɛ-caprolactone) micelle; NPPP/Bcl-2, Bcl-2 siRNA loaded nontargeted poly(ethylene glycol)– poly(ethylene imine)–poly(ɛ-caprolactone) micelle; FPPP/SCR, scrambled siRNA loaded folate–poly(ethylene glycol)–poly(ethylene imine)–poly(ɛ–caprolactone) micelle; NPPP/SCR, scrambled siRNA loaded nontargeted poly(ethylene glycol)– poly(ethylene imine)–poly(ɛ-caprolactone) micelle.