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. 2012 Jul 18;7:3823–3835. doi: 10.2147/IJN.S29328

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© 2012 Zou et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Protein expression levels of (A) Bcl-2 gene and (B) Bax gene determined by ELISA (n = 6).

Notes: Incubation time: 96 hours; Dose: 50 nM siRNA per well; N/P = 30. Statistics in A: *P < 0.05 compared with D-FPPP/Bcl-2; ^#P < 0.05 compared with B-FPPP/ Bcl-2; ^&P < 0.05 compared with D-FPPP/SCR; ^§P < 0.05 compared with D-NPPP/ SCR. Statistics in B: *P < 0.05 compared with D-FPPP/Bcl-2; ^&P < 0.05 compared with D-FPPP/SCR; ^§P < 0.05 compared with D-NPPP/SCR.

Abbreviations: DOX, doxorubicin; D-PPP, DOX loaded poly(ethylene glycol)– poly(ethylene imine)–poly(ɛ-caprolactone) micelle; B-PPP, blank–poly(ethylene glycol)–poly(ethylene imine)–poly(ɛ-caprolactone) micelle; FPPP/Bcl-2, Bcl-2 siRNA loaded folate–poly(ethylene glycol)–poly(ethylene imine)–poly(ɛ-caprolactone) micelle; NPPP/Bcl-2, Bcl-2 siRNA loaded nontargeted poly(ethylene glycol)– poly(ethylene imine)–poly(ɛ-caprolactone) micelle; FPPP/SCR, scrambled siRNA loaded folate–poly(ethylene glycol)–poly(ethylene imine)–poly(ɛ–caprolactone) micelle; NPPP/SCR, scrambled siRNA loaded nontargeted poly(ethylene glycol)– poly(ethylene imine)–poly(ɛ-caprolactone) micelle.