Table 5.

Particle size, zeta potential (ZP), polydispersity index (PDI), and pH of selected self-nanoemulsifying formulations

Samples	Particle size	ZP ± SEM (mV)	PDI	pH
	Size ± SEM (d nm)
Placebo NA-SNEDDSa	51.56 ± 0.07	−11.7 ± 1.25	0.106 ± 0.02	6.56
NA-SNEDDS, 0.5%	34.44 ± 0.16	6.76 ± 0.042	0.22 ± 0.003	4.94
NA-SNEDDS, 2%	38.49 ± 4.30	31.7 ± 3.58	0.318 ± 0.22	5.02
Placebo A-SNEDDSb	29.20 ± 0.173	−36.2 ± 2.79	0.190 ± 0.04	8.39
A-SNEDDS, 0.5%	33.79 ± 0.166	−27.2 ± 1.56	0.151 ± 0.01	8.49
A-SNEDDS, 2%	35 ± 2.80	−21.2 ± 3.46	0.28 ± 0.06	8.41

Notes: Data expressed as mean ± standard error of mean (n = 3).

^aNonalkalinized self-nanoemulsifying drug-delivery system loaded with 0.5% w/w raloxifene;

^balkalinized self-nanoemulsifying drug-delivery system loaded with 0.5% w/w raloxifene.