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. 2012 Sep;71(9):1510–1516. doi: 10.1136/annrheumdis-2011-200646

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Changes in adipocytokine serum levels after short- or long-term GC treatment. Serum levels of visfatin, resistin, vaspin, adiponectin and leptin from patients with RA were measured at baseline and after treatment. Individual changes after 2-week treatment with an oral GC (60 mg prednisolone daily for 1 week followed by 40 mg prednisolone daily for 1 week; GC cohort) compared with baseline are shown (A). Wilcoxon signed rank test was used to compare the changes for each adipocytokine. Median (IQR) change (expressed as percentage) after 21 weeks of combination treatment with oral dosages of hydroxychloroquine (400 mg/day), sulfasalazine (2 g/day), methotrexate (10 mg/week) and step-down high-dose prednisolone (tapered in 6 weeks from 60 to 7.5 mg/day (thereafter until end of trial); COBRA cohort) compared with baseline value (B). Wilcoxon signed rank test was used. *p=0.03; **p=0.02. GC, glucocorticoid; RA, rheumatoid arthritis.