Table 1.
A summary of the findings
| Case number | Sex | Age at onset (years) | Complications | Premorbid characters | Signs | Diagnosis (DSM-IV) | Effective drugs (daily dose) | Response |
|---|---|---|---|---|---|---|---|---|
| 1 | F | 10 | Active, mild, tidy, precise, obstinate, hardworking | Abulia, insomnia, mutism, withdrawal, OC, stereotypic behavior, self-laughing | Major Depressive Disorder Not Otherwise Specified (311) | Vegetamin A (phenobarbital 30 mg, chlorpromazine hydrochloride 25 mg, promethazine hydrochloride12.5 mg) | Improved | |
| 2 | F | 29 | Cataract | Cheerful, active, precise, hardworking | Slowness, abulia, withdrawal, OC, depressed mood, hypochondria | Major Depressive Disorder (296.2) | Fluvoxamine maleate 12.5–25 mg (selective serotonin reuptake inhibitor) | Improved |
| 3 | F | 25 | VSD, PDA, PH, Thyroid dysfunction | Cheerful, active, precise, hardworking | Slowness, insomnia, withdrawal, OC, depressed mood, agitation, mutism, self-talking | Obsessive–Compulsive Disorder (300.3) | Risperidone 2 mg, levomepromazine 10 mg, amantadine hydrochloride 100 mg | Partially improved |
| 4 | M | 24 | Cheerful, active, peaceful | Abulia, insomnia, withdrawal, delusions, anorexia, self-talking, tic, agitation, fatigue | Psychotic Disorder Not Otherwise Specified (298.9) | Haloperidol 1.5 mg, mexazolam 0.5 mg | Improved | |
| 5 | M | 18 | Hirschsprung disease | Peaceful | Abulia, insomnia, withdrawal, mutism, self-laughing | Adjustment Disorder (309.28) | Remitted without drugs | ND |
| 6 | M | 28 | Cataract | Peaceful, precise | Abulia, slowness, withdrawal, self-talking, fatigue | Major Depressive Disorder (296.2) | Not treated | ND |
| 7 | F | 20 | Cataract | Mild | Abulia, stupor, insomnia, depressed mood, mutism, morning depression | Major Depressive Disorder Not Otherwise Specified (311) | Bromazepam 4 mg | Partially improved |
| 8 | M | 18 | ASD, VSD, Epilepsy | Mild | Abulia, insomnia, OC, depressed mood, morning depression | Major Depressive Disorder Not Otherwise Specified (311) | Carbamazepine 300 mg | Partially improved |
| 9 | F | 28 | Fallot’s tetralogy | Cheerful, active, precise, hardworking | Abulia, insomnia, withdrawal, OC, depressed mood | Major Depressive Disorder (296.2) | Clomipramine 30 mg, nitrazepam 5 mg | Partially improved |
| 10 | F | 18 | ASD | Cheerful, active | Abulia, OC, delusions, hallucination, self-laughing, self-talking, agitation | Psychotic Disorder Not Otherwise Specified (298.9) | Haloperidol 3 mg, levomepromazine 50 mg, romethazine hydrochloride 50 mg | Partially improved |
| 11 | F | 21 | Precise, sensitive | Abulia, hypochondria, withdrawal, anorexia | Anxiety Disorder Not Otherwise Specified (300.00) | Fluvoxamine maleate 25 mg | Non-effective | |
| 12 | M | 23 | ASD, MI | Cheerful, mild, hardworking | Abulia, stupor, insomnia, withdrawal, tic | Major Depressive Disorder Not Otherwise Specified (311) | Amanthadine 150 mg, sulpiride 150 mg | Partially improved |
| 13 | M | 14 | ASD | Precise, peaceful, hardworking | Hypobulia, slowness, insomnia, OC, anorexia, tremor | Obsessive–Compulsive Disorder (300.3) | Clomipramine 30 mg | Partially improved |
Note: Mean age: 21.2 years.
Abbreviations: VSD, ventricular septal defect; OC, obsessive-compulsive behavior; ASD, atrial septal defect; PDA, patent ductus arteriosus; PH, pulmonary hypertension; MI, mitral isufficiency; ND, ; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, fourth edition.