Table 2.
Significant Results in Single SNP Analysis Adjusting for Clinical Variables
| Pathway | Gene | RS ID | Most Significant Results in Three Genetic Models: Odds Ratio (99% Confidence Interval) and P-Value |
Minimum P Value | ||
|---|---|---|---|---|---|---|
| Whole Case-Control Dataset | COPD Patients without Lung Cancer and Healthy Control Dataset | COPD Patients with Lung Cancer and Healthy Control Dataset | ||||
| GSH | ABCC1 | rs16967755 | 1.51(1.08 -2.10) | 1.50(0.95 -2.38) | 1.45(1.00 -2.10) | 1.60×10-3 |
| 1.60×10-3 | 2.36×10-2 | 1.01×10-2 | ||||
| GSH | ABCC4 | rs7324283 | 1.90(1.07 -3.37) | 2.40(1.17 -4.91) | 1.58(0.83 -3.04) | 1.60×10-3 |
| 3.93×10-3 | 1.60×10-3 | 6.88×10-2 | ||||
| GSH | GCLC | rs12524550 | 2.42(1.11 -5.28) | 2.60(0.92 -7.34) | 2.11(0.91 -4.90) | 3.54×10-3 |
| 3.54×10-3 | 1.79×10-2 | 2.28×10-2 | ||||
| GSH | GCLC | rs2100375 | 0.75(0.58 -.97) | 0.33(0.10 -1.04) | 0.78(0.58 -1.03) | 3.66×10-3 |
| 3.66×10-3 | 1.25×10-2 | 2.29×10-2 | ||||
| GSH | ABCC3 | rs8075406 | 0.70(0.50 -.97) | 0.65(0.41 -1.02) | 0.70(0.48 -1.01) | 4.88×10-3 |
| 4.88×10-3 | 1.45×10-2 | 1.17×10-2 | ||||
| GSH | ABCC4 | rs1729786 | 1.61(1.01 -2.56) | 1.43(1.03 -2.00) | 1.59(0.94 -2.70) | 5.67×10-3 |
| 8.91×10-3 | 5.67×10-3 | 2.29×10-2 | ||||
| GSH | GCLC | rs542914 | 0.78(0.62 -.99) | 0.80(0.58 -1.11) | 0.78(0.60 -1.02) | 6.26×10-3 |
| 6.26×10-3 | 7.70×10-2 | 1.68×10-2 | ||||
| GSH | GCLC | rs4712035 | 1.37(1.01 -1.86) | 1.38(0.86 -2.21) | 1.36(0.97 -1.90) | 7.01×10-3 |
| 7.01×10-3 | 8.41×10-2 | 1.76×10-2 | ||||
| GSH | GSTP1 | rs1138272 | 0.64(0.41 -1.00) | 0.76(0.42 -1.36) | 0.60(0.36 -.99) | 8.19×10-3 |
| 9.80×10-3 | 2.20×10-1 | 8.19×10-3 | ||||
| GSH | ABCC2 | rs717620 | 1.28(0.96 -1.72) | 1.87(0.57 -6.12) | 1.39(1.01 -1.94) | 8.80×10-3 |
| 2.77×10-2 | 1.74×10-1 | 8.80×10-3 | ||||
| GSH | GSS | rs6088659 | 0.29(0.09 -.99) | 0.39(0.07 -2.06) | 0.23(0.05 -1.01) | 9.22×10-3 |
| 9.22×10-3 | 1.47×10-1 | 1.06×10-2 | ||||
| GSH | ABCC2 | rs2756109 | 0.79(0.62 -1.00) | 0.69(0.43 -1.11) | 0.80(0.61 -1.04) | 9.34×10-3 |
| 9.34×10-3 | 4.35×10-2 | 2.55×10-2 | ||||
| GSH | ABCC1 | rs215100 | 0.65(0.38 -1.12) | 0.65(0.30 -1.41) | 0.76(0.58 -1.00) | 9.69×10-3 |
| 3.99×10-2 | 1.52×10-1 | 9.69×10-3 | ||||
| DNA | MSH3 | rs12513549 | 4.04(0.72 -22.80) | 8.68(1.36 -55.26) | 1.35(0.89 -2.05) | 2.63×10-3 |
| 3.75×10-2 | 2.63×10-3 | 6.64×10-2 | ||||
| DNA | XPA | rs1800975 | 0.85(0.62 -1.18) | 0.60(0.38 -.94) | 0.99(0.69 -1.42) | 3.33×10-3 |
| 2.05×10-1 | 3.33×10-3 | 9.26×10-1 | ||||
| DNA | PARP | rs11842915 | 1.26(0.93 -1.69) | 1.53(1.02 -2.28) | 1.14(0.77 -1.68) | 6.43×10-3 |
| 4.79×10-2 | 6.43×10-3 | 3.81×10-1 | ||||
| DNA | ×10RCC2 | rs3916874 | 1.31(1.01 -1.70) | 1.56(1.00 -2.46) | 1.28(0.96 -1.71) | 7.40×10-3 |
| 7.40×10-3 | 1.08×10-2 | 2.63×10-2 | ||||
| DNA | MSH3 | rs33013 | 0.72(0.52 -1.00) | 0.80(0.51 -1.26) | 0.69(0.48 -.99) | 8.42×10-3 |
| 1.01×10-2 | 2.11×10-1 | 8.42×10-3 | ||||
| DNA | MSH3 | rs12522132 | 2.17(0.58 -8.09) | 4.49(1.03 -19.52) | 1.22(0.83 -1.82) | 8.54×10-3 |
| 1.31×10-1 | 8.54×10-3 | 1.86×10-1 | ||||
| DNA | MSH3 | rs2897298 | 2.28(0.62 -8.32) | 4.48(1.03 -19.47) | 1.21(0.81 -1.79) | 8.58×10-3 |
| 1.03×10-1 | 8.58×10-3 | 2.17×10-1 | ||||
| Inflammation | PTGS2 | rs689470 | 2.26(0.96 -5.36) | 3.02(1.05 -8.71) | 1.96(0.72 -5.32) | 7.03×10-3 |
| 1.47×10-2 | 7.03×10-3 | 8.41×10-2 | ||||