Table 4.

Cumulative Risk Prediction Model for COPD Based on Multiple Independent High Risk HtSNP Combination

Number of Risk Alleles	Number of COPD Cases	Number of Healthy Controls	OR	S×10	Z	P-value
1. Whole Case-Control Dataset(12 risk htSNPs included)
First Level: [0,9]	99	219	1.00(reference)
Second Level: [10,12]	280	424	1.62	0.17	2.91	3.60×10-3
Third Level: [13,24]	241	250	2.73	0.18	5.61	2.07×10-8
Per-allele risk (trend test)			1.21	0.03	6.71	1.95×10-11
2. COPD Patients without Lung Cancer and Healthy Control Dataset (8 risk htSNPs included)
First Level: [0,2]	30	247	1.00(reference)
Second Level: [3,5]	108	496	1.67	0.24	2.19	2.83×10-2
Third Level: [6,16]	50	150	3.08	0.28	4.08	4.60×10-5
Per-allele risk (trend test)			1.25	0.05	4.76	1.94×10-6
3. COPD Patients with Lung Cancer and Healthy Control Dataset (4 risk htSNPs included)
First Level: [0,4]	124	324	1.00(reference)
Second Level: [5,6]	264	509	1.89	0.15	4.19	2.81×10-5
Third Level: [7,8]	44	60	2.32	0.27	3.10	1.94×10-3
Per-allele risk (trend test)			1.30	0.06	4.44	9.16×10-6