Table 3. Summary of Spearman correlations for pair of genes (promoter methylation) in thyroid samples.
| THYROID CANCER | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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RASSF1A |
0.56 * |
0.41 |
0.06 |
0.23 |
0.48 |
0.22 |
-0.11 |
0 |
0.08 |
-0.18 |
-0.15 |
0.14 |
0.33 |
-0.1 |
0.08 |
-0.13 |
0.24 |
0.11 |
0.04 |
-0.11 |
-0.06 |
| 0.61 * |
TSHR |
0.63 * |
0.6 * |
0.52 |
0.77 * |
0.47 |
0.15 |
-0.03 |
0.31 |
0.21 |
-0.04 |
0.04 |
0.36 |
-0.07 |
0.15 |
-0.18 |
0.1 |
0.26 |
0.1 |
0.15 |
-0.23 |
| 0.36 |
0.5 * |
CALCA |
0.68 |
0.37 |
0.45 |
0.25 |
0.27 |
0.34 |
0.33 |
0.36 |
-0.26 |
-0.1 |
0.36 |
0.06 |
0.04 |
-0.17 |
0.09 |
0.08 |
-0.21 |
0.02 |
-0.24 |
| 0.41 |
0.74 * |
0.48 |
CDH1 |
0.39 |
0.41 |
0.45 |
0.36 |
0.23 |
0.42 |
0.58 |
-0.03 |
0 |
0.4 |
-0.03 |
0.19 |
0.09 |
0.15 |
0.14 |
-0.18 |
0.33 |
-0.18 |
| 0.23 |
0.35 |
0.23 |
0.49 |
TIMP3 |
0.36 |
0.26 |
0.19 |
0.25 |
0.22 |
0.05 |
-0.04 |
-0.01 |
0.29 |
-0.16 |
0.21 |
-0.23 |
0.18 |
0.18 |
-0.1 |
0.24 |
-0.16 |
| 0.6 |
0.84 * |
0.49 |
0.66 |
0.27 |
TGFβR2 |
0.34 |
-0.07 |
-0.1 |
0.17 |
0.03 |
-0.08 |
0.06 |
0.32 |
-0.14 |
0.14 |
-0.27 |
0.02 |
0.51 |
0.06 |
0 |
-0.13 |
| 0.22 |
-0.05 |
-0.14 |
-0.16 |
0.1 |
-0.05 |
MINT1 |
-0.01 |
0.17 |
0.37 |
0.29 |
-0.02 |
0.05 |
0.37 |
0.1 |
0.43 |
-0.01 |
0 |
0.01 |
0.22 |
0.17 |
0.08 |
| 0.1 |
0.15 |
0.35 |
0.34 |
0.34 |
0.27 |
0.07 |
DCC |
0.37 |
0.25 |
0.25 |
-0.01 |
0.18 |
0.2 |
0.17 |
-0.1 |
-0.13 |
0.08 |
-0.07 |
-0.09 |
0.09 |
-0.1 |
| 0.22 |
0.23 |
0.01 |
0.27 |
0.17 |
0.22 |
0.02 |
0.14 |
MT1G |
0.12 |
0.22 |
-0.14 |
0.15 |
0.25 |
0.05 |
-0.04 |
-0.2 |
0.33 |
0.14 |
-0.04 |
0.18 |
-0.08 |
| -0.07 |
-0.05 |
0.03 |
0.05 |
0.1 |
0.02 |
0.14 |
-0.09 |
-0.08 |
RARβ2 |
0.25 |
-0.11 |
-0.09 |
0.15 |
0.15 |
0.18 |
-0.08 |
0.08 |
0.05 |
-0.03 |
0.26 |
-0.07 |
| -0.07 |
0.08 |
-0.01 |
0.16 |
0.29 |
-0.08 |
-0.35 |
-0.07 |
-0.04 |
-0.09 |
DAPK |
0.07 |
0.1 |
0.19 |
0.18 |
0.09 |
0.07 |
-0.02 |
-0.06 |
-0.15 |
0.27 |
-0.18 |
| -0.13 |
-0.19 |
-0.15 |
-0.14 |
-0.04 |
-0.24 |
-0.18 |
-0.09 |
0.32 |
-0.04 |
-0.12 |
GSTP1 |
-0.06 |
-0.13 |
-0.05 |
-0.13 |
0.15 |
0.08 |
0.11 |
0.15 |
0.17 |
-0.05 |
| 0.12 |
0.22 |
0.14 |
0.09 |
0.08 |
0.26 |
-0.18 |
-0.09 |
-0.08 |
-0.04 |
0.19 |
-0.04 |
p16 |
0.2 |
0.21 |
-0.1 |
-0.07 |
0.36 |
-0.01 |
-0.18 |
0.21 |
-0.04 |
| 0.09 |
0.16 |
0.04 |
0.12 |
0.13 |
0.21 |
0.13 |
-0.03 |
0.01 |
-0.1 |
0.09 |
-0.1 |
-0.1 |
THBS1 |
0.04 |
0.16 |
0.07 |
0.08 |
0.15 |
-0.17 |
0.03 |
-0.07 |
| 0.03 |
-0.11 |
-0.06 |
0.05 |
0.11 |
-0.08 |
0.16 |
0.19 |
0.06 |
-0.17 |
-0.16 |
0.01 |
-0.17 |
0.2 |
S100A2 |
0.06 |
-0.04 |
0.05 |
-0.1 |
-0.02 |
0.18 |
-0.14 |
| -0.05 |
0.01 |
-0.01 |
-0.02 |
-0.22 |
0.06 |
-0.22 |
-0.15 |
-0.15 |
-0.04 |
-0.1 |
-0.04 |
-0.04 |
0.25 |
-0.24 |
CTNNB1 |
0.06 |
0.01 |
-0.05 |
0.09 |
0.03 |
-0.07 |
| 0.1 |
0.22 |
0.19 |
0.21 |
0 |
0.22 |
-0.22 |
-0.18 |
-0.04 |
-0.01 |
0.1 |
-0.15 |
0.24 |
0.18 |
-0.18 |
0.36 |
hMLH1 |
-0.07 |
-0.14 |
0.1 |
-0.04 |
-0.08 |
| -0.03 |
0 |
0.1 |
-0.02 |
0.09 |
-0.03 |
0.1 |
-0.09 |
0.05 |
0.16 |
-0.17 |
-0.16 |
-0.16 |
0.03 |
0 |
0.32 |
0.01 |
ATM |
0.04 |
-0.04 |
0.43 |
-0.2 |
| -0.04 |
0.05 |
0.12 |
0.01 |
-0.21 |
0.04 |
-0.05 |
0.16 |
0.16 |
-0.1 |
-0.1 |
-0.1 |
. |
-0.14 |
-0.15 |
0.01 |
0 |
0.24 |
PAK3 |
0.16 |
0.11 |
0.04 |
| 0.19 |
0.07 |
-0.13 |
-0.13 |
0.06 |
0.06 |
0.26 |
-0.25 |
0.1 |
0.2 |
-0.11 |
-0.2 |
. |
0.23 |
0.2 |
0.05 |
0.17 |
0.16 |
0.13 |
NISCH |
-0.06 |
-0.25 |
| . |
. |
. |
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. |
. |
. |
. |
. |
. |
. |
. |
KIF1A |
-0.07 |
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
AIM1 |
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THYROID NORMAL + BENIGN PATHOLOGY |
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The diagonal row of boxes lists the markers analyzed; correlations are indicated at the horizontal and vertical intersections of the markers. Light gray shading represents R > 0.5; dark gray shading represents R > 0.7. The samples were split into two groups: correlation between the pair of genes in tumors (n = 44) indicated in the upper half of the plot and correlations between normal (benign pathology and normal thyroid tissue, n = 59) indicated in the lower half of the plot. Black asterisk (*) indicates similar correlations observed in both groups. Black dot (.) indicates that the correlation could not be calculated due to values being mainly zero.