A. Fragmentation of the [M-2H]2− ion peak at m/z 814.457 corresponding to C60 dolichol phosphate modified by a 711.2 Da tetrasaccharide comprising deoxyhexose, two hexoses and a sulfated or phosphorylated hexose.
B. Fragmentation of the [M-2H]2− ion peak at m/z 660.373 corresponding to C60 dolichol phosphate modified by the disaccharide precursor of the tetrasaccharide-modified species examined in (A).
In (A) and (B), the insets show the chemical structure of the glycan-charged C60 dolichol phosphate and the MS/MS fragmentation scheme of the [M-2H]2− ion. In addition, the chemical formula and exact mass are provided.
C. Product ion spectra showing SO3− and PO3− groups released from disaccharide-modified C60 dolichol phosphate from cells grown in 1.75 M NaCl. The inset shows the predicted isotopic distribution of SO3− (upper panel) and PO3− (lower panel) ions.