Figure 6. Cnx Is Expressed in the ER of All Eight Photoreceptor Cells.

Confocal images of cross-sections from wt eyes immunolabeled with polyclonal rabbit antibodies directed to (top) Cnx, (middle) InsP₃R, and (bottom) NinaA. Nuclei were stained with ToPro3 (blue). (Arrows) Perinuclear labeling; (arrowhead) nonspecific labeling of R7 rhabdomere with the InsP₃R antibody. (Below) A schematic of a cross-section from the R1-7 photoreceptor cells. The rhabdomere (R) is the photosensitive organelle comprised of numerous microvili containing the rhodopsin photopigments and the other components of the phototransduction cascade. The endoplasmic reticular (ER) membrane system (red)is extensive in the photoreceptor cells and is perinuclear as well as elsewhere in the photoreceptor cells, nuclei (N, blue).