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. 2012 Aug 8;7(8):e42769. doi: 10.1371/journal.pone.0042769

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© 2012 Li et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The biosynthetic pathway of UDP-GlcNAc in prokaryotes and eukaryotes were different. In prokaryotes, UDP-GlcNAc was biosynthesized through reactions (1), (2), (3) and (6); In eukaryotes, UDP-GlcNAc was formed through reactions (1), (4), (5) and (6). The reactions catalyzed by phosphoglucosamine mutase (GlmM) and glucosamine-1-phosphate acetyl transferase (GlmU) were unique to prokaryotes.