. 2012 Aug 8;7(8):e42343. doi: 10.1371/journal.pone.0042343

Table 7. Statistical analyses comparing pathology and virology scores among ferrets inoculated with different influenza viruses.

		Significance of the difference (P-value)
		Pathology scores				Virology scores
Comparison	Day	Percentage of affected lung tissue	Relative lung weight (%)	Extent and severity of alveolitis and alveolar damage (Score 0–3)	Percentage of air containing space in pulmonary tissue (Digital scoring)	Virus titers lung tissue (log₁₀ TCID₅₀ per gram)	Antigen expression in the alveoli by immunohistochemistry (%)	Percentage of antigen expression in the alveoli (Digital scoring)	Number of antigen expression counts in the alveoli (Digital scoring)
H3N2 versus pH1N1	0.5	0.739	0.248	0.245	1.000	0.020^*	0.019^*	0.021^*	0.020^*
	1	0.017^*	0.021^*	0.019^*	0.773	0.021^*	0.018^*	0.021^*	0.018^*
	2	0.018^*	0.021^*	0.019^*	0.773	0.021^*	0.018^*	0.018^*	0.017^*
	3	0.013^*	0.021^*	0.021^*	0.386	0.021^*	0.017^*	0.021^*	0.076
	4	0.011^*	0.021^*	0.019^*	0.021^*	0.020^*	0.014^*	0.018^*	0.026^*
	7	0.014^*	0.021^*	0.019^*	0.386	0.245	0.014^*	0.772	0.439
	14	0.017^*	0.021^*	0.020^*	0.564	0.309	1.000	0.508	0.508
H3N2 versus H5N1	0.5	0.036^*	0.083	0.020^*	0.386	0.020^*	0.019^*	0.021^*	0.020^*
	1	0.028^*	0.083	0.019^*	0.021^*	0.021^*	0.018^*	0.021^*	0.018^*
	2	0.009^**	0.011^*	0.010^*	0.019^*	0.011^*	0.009^**	0.010^*	0.010^*
	3	0.019^*	0.034^*	0.032^*	0.034^*	0.034^*	0.028^*	0.034^*	0.032^*
	4	0.019^*	0.034^*	0.031^*	0.077	0.032^*	0.019^*	0.028^*	0.028^*
pH1N1 versus H5N1	0.5	0.052	0.083	0.110	0.564	0.021^*	0.083	0.386	0.386
	1	0.757	1.000	1.000	0.083	0.021^*	0.083	0.043^*	0.773
	2	0.009^**	0.019^*	0.010^*	0.011^*	0.831	0.054	0.201	0.032^*
	3	0.048^*	0.034^*	0.285	0.034^*	0.724	0.032^*	0.034^*	0.034^*
	4	0.067	0.034^*	0.064	0.034^*	0.157	0.593	0.724	0.289

P-values were calculated by using the Mann-Whitney test.

P-value<0.05.

^**

P-value<0.01.