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. 2012 Aug 8;7(8):e42059. doi: 10.1371/journal.pone.0042059

Figure 13. The effect of feedback inhibition to ORX cells from REM-off neurons.

Figure 13

The simulation begins withInline graphic. This amount of feedback inhibition did not qualitatively change the basic sleep-wake cycling (compare with Fig. 3). At time t1, the feedback inhibition was changed to 0.5. The system was no longer able to stay in a prolonged state of sleep; sleep bouts were continually disrupted by brief awakenings. At time t2,Inline graphicwas set to 0, which destroyed the cycling. At time t3Inline graphicwas reset to 0.1 while gh was increased to 7 which restored the normal cycling.